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spio contrast agent  (Bayer Schering Pharma)
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Representative <t>SPIO-enhanced</t> MRI appearances of lymph nodes. (A) Post-SPIO T2*-weighted image of a reactive hyperplastic axillary lymph node (arrow) demonstrating marked signal loss, consistent with macrophage-mediated iron uptake. (B) Post-SPIO T2*-weighted image of a metastatic axillary lymph node (arrow) showing preserved signal intensity, consistent with reduced iron uptake due to tumor cell replacement of normal lymphoid tissue. Field strength: 3.0 T; imaging performed 12 h after intravenous administration of <t>SPIO</t> <t>(Resovist,</t> 0.2 mL/kg).
Spio Contrast Agent, supplied by Bayer Schering Pharma, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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spio injection  (Siemens Healthineers)
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Representative <t>SPIO-enhanced</t> MRI appearances of lymph nodes. (A) Post-SPIO T2*-weighted image of a reactive hyperplastic axillary lymph node (arrow) demonstrating marked signal loss, consistent with macrophage-mediated iron uptake. (B) Post-SPIO T2*-weighted image of a metastatic axillary lymph node (arrow) showing preserved signal intensity, consistent with reduced iron uptake due to tumor cell replacement of normal lymphoid tissue. Field strength: 3.0 T; imaging performed 12 h after intravenous administration of <t>SPIO</t> <t>(Resovist,</t> 0.2 mL/kg).
Spio Injection, supplied by Siemens Healthineers, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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spio nws  (Dawley Inc)
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Representative <t>SPIO-enhanced</t> MRI appearances of lymph nodes. (A) Post-SPIO T2*-weighted image of a reactive hyperplastic axillary lymph node (arrow) demonstrating marked signal loss, consistent with macrophage-mediated iron uptake. (B) Post-SPIO T2*-weighted image of a metastatic axillary lymph node (arrow) showing preserved signal intensity, consistent with reduced iron uptake due to tumor cell replacement of normal lymphoid tissue. Field strength: 3.0 T; imaging performed 12 h after intravenous administration of <t>SPIO</t> <t>(Resovist,</t> 0.2 mL/kg).
Spio Nws, supplied by Dawley Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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superparamagnetic iron oxide (spio) nanoparticles, synomag  (MicroMod Partikeltechnologie GmbH)
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Representative <t>SPIO-enhanced</t> MRI appearances of lymph nodes. (A) Post-SPIO T2*-weighted image of a reactive hyperplastic axillary lymph node (arrow) demonstrating marked signal loss, consistent with macrophage-mediated iron uptake. (B) Post-SPIO T2*-weighted image of a metastatic axillary lymph node (arrow) showing preserved signal intensity, consistent with reduced iron uptake due to tumor cell replacement of normal lymphoid tissue. Field strength: 3.0 T; imaging performed 12 h after intravenous administration of <t>SPIO</t> <t>(Resovist,</t> 0.2 mL/kg).
Superparamagnetic Iron Oxide (Spio) Nanoparticles, Synomag, supplied by MicroMod Partikeltechnologie GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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spio agent magtrace  (Endomagnetics Limited)
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Representative <t>SPIO-enhanced</t> MRI appearances of lymph nodes. (A) Post-SPIO T2*-weighted image of a reactive hyperplastic axillary lymph node (arrow) demonstrating marked signal loss, consistent with macrophage-mediated iron uptake. (B) Post-SPIO T2*-weighted image of a metastatic axillary lymph node (arrow) showing preserved signal intensity, consistent with reduced iron uptake due to tumor cell replacement of normal lymphoid tissue. Field strength: 3.0 T; imaging performed 12 h after intravenous administration of <t>SPIO</t> <t>(Resovist,</t> 0.2 mL/kg).
Spio Agent Magtrace, supplied by Endomagnetics Limited, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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spio coated with carboxydextran  (Endomagnetics Limited)
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Representative <t>SPIO-enhanced</t> MRI appearances of lymph nodes. (A) Post-SPIO T2*-weighted image of a reactive hyperplastic axillary lymph node (arrow) demonstrating marked signal loss, consistent with macrophage-mediated iron uptake. (B) Post-SPIO T2*-weighted image of a metastatic axillary lymph node (arrow) showing preserved signal intensity, consistent with reduced iron uptake due to tumor cell replacement of normal lymphoid tissue. Field strength: 3.0 T; imaging performed 12 h after intravenous administration of <t>SPIO</t> <t>(Resovist,</t> 0.2 mL/kg).
Spio Coated With Carboxydextran, supplied by Endomagnetics Limited, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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superparamagnetic iron oxide spio magtrace  (Endomagnetics Limited)
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Endomagnetics Limited superparamagnetic iron oxide spio magtrace
Representative <t>SPIO-enhanced</t> MRI appearances of lymph nodes. (A) Post-SPIO T2*-weighted image of a reactive hyperplastic axillary lymph node (arrow) demonstrating marked signal loss, consistent with macrophage-mediated iron uptake. (B) Post-SPIO T2*-weighted image of a metastatic axillary lymph node (arrow) showing preserved signal intensity, consistent with reduced iron uptake due to tumor cell replacement of normal lymphoid tissue. Field strength: 3.0 T; imaging performed 12 h after intravenous administration of <t>SPIO</t> <t>(Resovist,</t> 0.2 mL/kg).
Superparamagnetic Iron Oxide Spio Magtrace, supplied by Endomagnetics Limited, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Representative SPIO-enhanced MRI appearances of lymph nodes. (A) Post-SPIO T2*-weighted image of a reactive hyperplastic axillary lymph node (arrow) demonstrating marked signal loss, consistent with macrophage-mediated iron uptake. (B) Post-SPIO T2*-weighted image of a metastatic axillary lymph node (arrow) showing preserved signal intensity, consistent with reduced iron uptake due to tumor cell replacement of normal lymphoid tissue. Field strength: 3.0 T; imaging performed 12 h after intravenous administration of SPIO (Resovist, 0.2 mL/kg).

Journal: Frontiers in Medicine

Article Title: SPIO-enhanced MRI for differentiating metastatic from reactive hyperplastic lymph nodes in breast cancer: diagnostic performance and association with VEGF-C expression

doi: 10.3389/fmed.2026.1800084

Figure Lengend Snippet: Representative SPIO-enhanced MRI appearances of lymph nodes. (A) Post-SPIO T2*-weighted image of a reactive hyperplastic axillary lymph node (arrow) demonstrating marked signal loss, consistent with macrophage-mediated iron uptake. (B) Post-SPIO T2*-weighted image of a metastatic axillary lymph node (arrow) showing preserved signal intensity, consistent with reduced iron uptake due to tumor cell replacement of normal lymphoid tissue. Field strength: 3.0 T; imaging performed 12 h after intravenous administration of SPIO (Resovist, 0.2 mL/kg).

Article Snippet: The SPIO contrast agent (Resovist; Bayer Schering Pharma; ferucarbotran) was administered intravenously at a dose of 0.2 mL/kg (approximately 0.56 mg Fe/kg), followed by a saline flush.

Techniques: Imaging